Chromosome 21 Gain Is Dispensable for Transient Myeloproliferative Disorder (TMD) Development
نویسندگان
چکیده
منابع مشابه
Down's syndrome with transient myeloproliferative disorder.
Children with Down's syndrome are at an increased risk for development of several hematological disorders like acute leukemia, acute myelofibrosis of childhood and transient myeloproliferative disorder (TMD)(1). Transient myeloproliferative disorder is recognized shortly after birth or in neonatal period and is characterized by leukocytosis and thrombocytopenia, which resolves spontaneously in ...
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Hong Kong Med J ⎥ Volume 20 Number 1 ⎥ February 2014 ⎥ www.hkmj.org A 39-year-old Rhesus-positive mother had been well. She had been screened low risk (1:2496) for Down syndrome (DS) at the first-trimester combined screening in late 2012. The fetal morphology scan at 20 weeks of gestation was normal. Nevertheless, an ultrasound scan at 32 weeks of gestation showed bilateral pleural effusions. A...
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Transient myeloproliferative disorder is a hematological condition observed during the neonatal period in patients with Down syndrome [1]. This disorder mimics congenital leukemia and the blast cells were often reported to show characteristics compatible with those of megakaryoblasts [2] or pluripotent stem cells [3]. Although this disorder usually resolves gradually without antileukemic treatm...
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ژورنال
عنوان ژورنال: Blood
سال: 2018
ISSN: 0006-4971,1528-0020
DOI: 10.1182/blood-2018-99-112078